Occupational exposures and the risk of amyotrophic lateral sclerosis.

ABSTRACT:

Objectives

To examine the associations of specific occupations and occupational exposures with the risk of amyotrophic lateral sclerosis (ALS) in the Swedish population.

Methods

A nested case-control study was conducted in Sweden. Patients with ALS diagnosed during 1991-2010 (n=5020) were identified from the National Patient Register and 5 controls per case (n=25 100) were randomly selected from the general Swedish population, individually matched to cases by birth year and sex. Occupational history was obtained from the Swedish censuses in 1970, 1980 and 1990. The Nordic Occupational Cancer Study Job Exposure Matrix was used to identify exposures related to individual occupations. Conditional logistic regression was used to estimate ORs and their 95% CIs.

Results

Hig

SUBMITTER: Peters TL 

PROVIDER: S-EPMC5451107 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature