Cystatin C and Cardiovascular Disease: A Mendelian Randomization Study.

ABSTRACT:

Background

Epidemiological studies show that high circulating cystatin C is associated with risk of cardiovascular disease (CVD), independent of creatinine-based renal function measurements. It is unclear whether this relationship is causal, arises from residual confounding, and/or is a consequence of reverse causation.

Objectives

The aim of this study was to use Mendelian randomization to investigate whether cystatin C is causally related to CVD in the general population.

Methods

We incorporated participant data from 16 prospective cohorts (n = 76,481) with 37,126 measures of cystatin C and added genetic data from 43 studies (n = 252,216) with 63,292 CVD events. We used the common variant rs911119 in CST3 as an instrumental variable to investigate the causal role of

SUBMITTER: van der Laan SW 

PROVIDER: S-EPMC5451109 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature