Characterization of single cell derived cultures of periosteal progenitor cells to ensure the cell quality for clinical application.

ABSTRACT: For clinical applications of cells and tissue engineering products it is of importance to characterize the quality of the used cells in detail. Progenitor cells from the periosteum are already routinely applied in the clinics for the regeneration of the maxillary bone. Periosteal cells have, in addition to their potential to differentiate into bone, the ability to develop into cartilage and fat. However, the question arises whether all cells isolated from periosteal biopsies are able to differentiate into all three tissue types, or whether there are subpopulations. For an efficient and approved application in bone or cartilage regeneration the clarification of this question is of interest. Therefore, 83 different clonal cultures of freshly isolated human periosteal cells derived from masto

SUBMITTER: Stich S 

PROVIDER: S-EPMC5451110 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature