Intermittent glucocorticoid steroid dosing enhances muscle repair without eliciting muscle atrophy.

ABSTRACT: Glucocorticoid steroids such as prednisone are prescribed for chronic muscle conditions such as Duchenne muscular dystrophy, where their use is associated with prolonged ambulation. The positive effects of chronic steroid treatment in muscular dystrophy are paradoxical because these steroids are also known to trigger muscle atrophy. Chronic steroid use usually involves once-daily dosing, although weekly dosing in children has been suggested for its reduced side effects on behavior. In this work, we tested steroid dosing in mice and found that a single pulse of glucocorticoid steroids improved sarcolemmal repair through increased expression of annexins A1 and A6, which mediate myofiber repair. This increased expression was dependent on glucocorticoid response elements upstream of annexins a

SUBMITTER: Quattrocelli M 

PROVIDER: S-EPMC5451235 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature