Rare coding variants associated with blood pressure variation in 15 914 individuals of African ancestry.

ABSTRACT:

Objectives

Hypertension is a major risk factor for all cardiovascular diseases, especially among African Americans. This study focuses on identifying specific blood pressure (BP) genes using 15 914 individuals of African ancestry from eight cohorts (Africa America Diabetes Mellitus, Atherosclerosis Risk in Communities Study, Coronary Artery Risk Development in young Adults, Genetics Network, Genetic Epidemiology Network of Arteriopathy, Howard University Family Study, Hypertension Genetic Epidemiology Network, and Loyola University Chicago Cohort) to further genetic findings in this population which has generally been underrepresented in BP studies.

Methods

We genotyped and performed various single variant and gene-based exome-wide analyses on 15 914 individuals on the Illum

SUBMITTER: Nandakumar P 

PROVIDER: S-EPMC5451310 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature