Cdk6 contributes to cytoskeletal stability in erythroid cells.

ABSTRACT: Mice lacking Cdk6 kinase activity suffer from mild anemia accompanied by elevated numbers of Ter119⁺ cells in the bone marrow. The animals show hardly any alterations in erythroid development, indicating that Cdk6 is not required for proliferation and maturation of erythroid cells. There is also no difference in stress erythropoiesis following hemolysis in vivo However, Cdk6^-/- erythrocytes have a shortened lifespan and are more sensitive to mechanical stress in vitro, suggesting differences in cytoskeletal architecture. Erythroblasts contain both Cdk4 and Cdk6, while mature erythrocytes apparently lack Cdk4 and their Cdk6 is partly associated with the cytoskeleton. We used mass spectrometry to show that Cdk6 interacts with a number of proteins in

SUBMITTER: Uras IZ 

PROVIDER: S-EPMC5451331 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature