α₇β₁ Integrin regulation of gene transcription in skeletal muscle following an acute bout of eccentric exercise.

ABSTRACT: The α₇β₁ integrin is concentrated at the costameres of skeletal muscle and provides a critical link between the actin cytoskeleton and laminin in the basement membrane. We previously demonstrated that expression of the α₇BX2 integrin subunit (MCK:α₇BX2) preserves muscle integrity and enhances myofiber cross-sectional area following eccentric exercise. The purpose of this study was to utilize gene expression profiling to reveal potential mechanisms by which the α₇BX2-integrin contributes to improvements in muscle growth after exercise. A microarray analysis was performed using RNA extracted from skeletal muscle of wild-type or transgenic mice under sedentary conditions and 3 h following an acute bout of downhill running. Genes with fals

SUBMITTER: Mahmassani ZS 

PROVIDER: S-EPMC5451518 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature