Two weeks of moderate-intensity continuous training, but not high-intensity interval training, increases insulin-stimulated intestinal glucose uptake.

ABSTRACT: Similar to muscles, the intestine is also insulin resistant in obese subjects and subjects with impaired glucose tolerance. Exercise training improves muscle insulin sensitivity, but its effects on intestinal metabolism are not known. We studied the effects of high-intensity interval training (HIIT) and moderate-intensity continuous training (MICT) on intestinal glucose and free fatty acid uptake from circulation in humans. Twenty-eight healthy, middle-aged, sedentary men were randomized for 2 wk of HIIT or MICT. Intestinal insulin-stimulated glucose uptake and fasting free fatty acid uptake from circulation were measured using positron emission tomography and [¹⁸F]FDG and [¹⁸F]FTHA. In addition, effects of HIIT and MICT on intestinal GLUT2 and CD36 protein expression

SUBMITTER: Motiani KK 

PROVIDER: S-EPMC5451533 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature