Cough and expiration reflexes elicited by inhaled irritant gases are intensified in ovalbumin-sensitized mice.

ABSTRACT: This study was designed to determine the effect of active sensitization with ovalbumin (Ova) on cough responses to inhaled irritant gases in mice. Conscious mice moved freely in a recording chamber, while the pressure change in the chamber and audio and video signals of the mouse movements were recorded simultaneously to measure the frequencies of cough reflex (CR) and expiration reflex (ER). To further verify the accuracy of cough analysis, the intrapleural pressure was also recorded by a telemetry sensor surgically implanted in the intrapleural space in a subgroup of mice. During the irritant gas inhalation challenge, sulfur dioxide (SO₂; 200 and 400 ppm) or ammonia (NH₃; 0.1% and 0.2%) was drawn into the chamber at a constant flow rate for 8 min. Ova sensitization

SUBMITTER: Zhang C 

PROVIDER: S-EPMC5451571 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature