Hydrogen sulfide alleviates hypertensive kidney dysfunction through an epigenetic mechanism.

ABSTRACT: Hypertension is a major risk factor for chronic kidney disease (CKD), and renal inflammation is an integral part in this pathology. Hydrogen sulfide (H₂S) has been shown to mitigate renal damage through reduction in blood pressure and ROS; however, the exact mechanisms are not clear. While several studies have underlined the role of epigenetics in renal inflammation and dysfunction, the mechanisms through which epigenetic regulators play a role in hypertension are not well defined. In this study, we sought to identify whether microRNAs are dysregulated in response to angiotensin II (ANG II)-induced hypertension in the kidney and whether a H₂S donor, GYY4137, could reverse the microRNA alteration and kidney function. Wild-type (C57BL/6J) mice were treated without or wi

SUBMITTER: Weber GJ 

PROVIDER: S-EPMC5451583 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature