Procalcitonin-Guided Antibiotics after Surgery for Peritonitis: A Randomized Controlled Study.

ABSTRACT:

Background

Serum procalcitonin (PCT) is a useful biomarker to tailor the duration of antibiotics in respiratory infections. The objective of this study was to determine whether PCT levels could tailor postoperative antibiotic therapy in patients operated for peritonitis.

Method

Patients with peritonitis were randomized postoperatively. The control group received antibiotics for a defined duration according to institutional guidelines. In the study group, antibiotics were stopped based on serum PCT levels. Patients were stratified into three categories: (1) gastrointestinal perforation, (2) perforated appendicitis, and (3) postoperative complication. Primary outcome was duration of antibiotics.

Results

We included 162 patients; 83 and 79 patients in the control group a

SUBMITTER: Slieker JC 

PROVIDER: S-EPMC5451779 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature