Rexin-G^®, a tumor-targeted retrovector for malignant peripheral nerve sheath tumor: A case report.

ABSTRACT: Soft tissue sarcoma is a rare neoplasm of mesenchymal origin, accounting for only ~1% of all adult cancers and consisting of 75 histological subtypes. In the present report, the unique case of a 14 year-old female with metastatic malignant peripheral nerve sheath tumor (formerly, malignant melanotic schwannoma) of the parotid gland, who experienced a durable response and sustained tumor control with Rexin-G^®, a tumor-targeted retroviral expression vector encoding an anti-cyclin G1 construct, is described. Post-parotidectomy, and prior to the administration of Rexin-G^®, the patient received various chemotherapy regimens, including doxorubicin, ifosfamide, temozolomide, sorafenib, and an immunological therapy with interleukin-2, which only resulted in the further progre

SUBMITTER: Kim S 

PROVIDER: S-EPMC5451875 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature