The transcription factor bZIP14 regulates the TCA cycle in the diatom Phaeodactylum tricornutum.

ABSTRACT: Diatoms are amongst the most important marine microalgae in terms of biomass, but little is known concerning the molecular mechanisms that regulate their versatile metabolism. Here, the pennate diatom Phaeodactylum tricornutum was studied at the metabolite and transcriptome level during nitrogen starvation and following imposition of three other stresses that impede growth. The coordinated upregulation of the tricarboxylic acid (TCA) cycle during the nitrogen stress response was the most striking observation. Through co-expression analysis and DNA binding assays, the transcription factor bZIP14 was identified as a regulator of the TCA cycle, also beyond the nitrogen starvation response, namely in diurnal regulation. Accordingly, metabolic and transcriptional shifts were observed upo

SUBMITTER: Matthijs M 

PROVIDER: S-EPMC5452028 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature