Carbon dating cancer: defining the chronology of metastatic progression in colorectal cancer.

ABSTRACT:

Background

Patients often ask oncologists how long a cancer has been present before causing symptoms or spreading to other organs. The evolutionary trajectory of cancers can be defined using phylogenetic approaches but lack of chronological references makes dating the exact onset of tumours very challenging.

Patients and methods

Here, we describe the case of a colorectal cancer (CRC) patient presenting with synchronous lung metastasis and metachronous thyroid, chest wall and urinary tract metastases over the course of 5 years. The chest wall metastasis was caused by needle tract seeding, implying a known time of onset. Using whole genome sequencing data from primary and metastatic sites we inferred the complete chronology of the cancer by exploiting the time of needle tract

SUBMITTER: Lote H 

PROVIDER: S-EPMC5452067 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature