Neuronal Chloride Regulation via KCC2 Is Modulated through a GABA_B Receptor Protein Complex.

ABSTRACT: GABA_B receptors are G-protein-coupled receptors that mediate inhibitory synaptic actions through a series of downstream target proteins. It is increasingly appreciated that the GABA_B receptor forms part of larger signaling complexes, which enable the receptor to mediate multiple different effects within neurons. Here we report that GABA_B receptors can physically associate with the potassium-chloride cotransporter protein, KCC2, which sets the driving force for the chloride-permeable ionotropic GABA_A receptor in mature neurons. Using biochemical, molecular, and functional studies in rodent hippocampus, we show that activation of GABA_B receptors results in a decrease in KCC2 function, which is associated with a reduction in the protein a

SUBMITTER: Wright R 

PROVIDER: S-EPMC5452337 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature