Human papillomavirus type distribution and HPV16 intratype diversity in southern Brazil in women with and without cervical lesions.

ABSTRACT:

Background

Increasing evidence suggests that human papillomavirus (HPV) intratype variants (specific lineages and sublineages) are associated with pathogenesis and progression from HPV infection to persistence and the development of cervical cancer.

Objectives

This study aimed to verify the prevalence of HPV infection and distribution of HPV types and HPV16 variants in southern Brazil in women with normal cytology or intraepithelial lesions.

Methods

HPV typing was determined by L1 gene sequencing. To identify HPV16 variants, the LCR and E6 regions were sequenced, and characteristic single nucleotide variants were identified.

Findings

A total of 445 samples were studied, with 355 from cervical scrapes and 90 from cervical biopsies. HPV was detected in 24% and 91

SUBMITTER: de Oliveira GR 

PROVIDER: S-EPMC5452486 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature