Modeling the cis-regulatory modules of genes expressed in developmental stages of Drosophila melanogaster.

ABSTRACT: Because transcription is the first step in the regulation of gene expression, understanding how transcription factors bind to their DNA binding motifs has become absolutely necessary. It has been shown that the promoters of genes with similar expression profiles share common structural patterns. This paper presents an extensive study of the regulatory regions of genes expressed in 24 developmental stages of Drosophila melanogaster. It proposes the use of a combination of structural features, such as positioning of individual motifs relative to the transcription start site, orientation, pairwise distance between motifs, and presence of motifs anywhere in the promoter for predicting gene expression from structural features of promoter sequences. RNA-sequencing data was utilized to cre

SUBMITTER: Lopez Y 

PROVIDER: S-EPMC5452948 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature