Clinical impact of human papillomavirus in laryngeal squamous cell carcinoma: a retrospective study.

ABSTRACT:

Objectives

The purpose of this study is to determine the prevalence and clinical impact of human papillomavirus (HPV) related laryngeal squamous cell carcinoma (LSCC).

Methods

A total of 106 LSCC patients who underwent primary surgical resection with or without adjuvant radiotherapy/chemoradiotherapy were enrolled retrospectively. Tumors collected from paraffin-embedded samples were used for HPV detection by polymerase chain reaction and in situ hybridization technique. Clinicopathological parameters were recorded for analysis.

Results

The prevalence of HPV in patients with LSCC was 13.2% in our series and 12 out of 14 (85.7%) HPV-positive tumors were HPV-16. The patients with HPV-positive tumors were older (p = 0.042), less local/regional recurrence (p 

SUBMITTER: Chen WC 

PROVIDER: S-EPMC5452968 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature