Synthesis, characterization and antitumor activity of Ln(III) complexes with hydrazone Schiff base derived from 2-acetylpyridine and isonicotinohydrazone.

ABSTRACT: In the present study, two isostructural lanthanide (Ln)(III) complexes, namely Ln(HL)₂(NO₃)(CH₃OH)₂)·CH₃OH, where Ln = La in complex 1 and Ce in complex 2, and hydrogen ligand (HL) = (E)-N'-[1-(2-pyridinyl)ethylidene]isonicotinohydrazone, have been isolated and characterized by elemental analysis, infrared spectra and single-crystal X-ray diffraction analysis. The results revealed that the acylhydrazone ligand HL in each complex was deprotonated as an anionic ligand and coordinated to the central La(III) ion via enolization of oxygen and nitrogen atoms. Furthermore, the antitumor effects and potential mechanisms of the two complexes were explored in the human lung cancer cell line A549 and in the human gastric cancer cell lines BGC823

SUBMITTER: Xie J 

PROVIDER: S-EPMC5453057 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature