Mycobacterium tuberculosis EsxH inhibits ESCRT-dependent CD4⁺ T-cell activation.

ABSTRACT: Mycobacterium tuberculosis (Mtb) establishes a persistent infection, despite inducing antigen-specific T-cell responses. Although T cells arrive at the site of infection, they do not provide sterilizing immunity. The molecular basis of how Mtb impairs T-cell function is not clear. Mtb has been reported to block major histocompatibility complex class II (MHC-II) antigen presentation; however, no bacterial effector or host-cell target mediating this effect has been identified. We recently found that Mtb EsxH, which is secreted by the Esx-3 type VII secretion system, directly inhibits the endosomal sorting complex required for transport (ESCRT) machinery. Here, we showed that ESCRT is required for optimal antigen processing; correspondingly, overexpression and loss-of-function studies demonst

SUBMITTER: Portal-Celhay C 

PROVIDER: S-EPMC5453184 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature