A comparative analysis of whole genome sequencing of esophageal adenocarcinoma pre- and post-chemotherapy.

ABSTRACT: The scientific community has avoided using tissue samples from patients that have been exposed to systemic chemotherapy to infer the genomic landscape of a given cancer. Esophageal adenocarcinoma is a heterogeneous, chemoresistant tumor for which the availability and size of pretreatment endoscopic samples are limiting. This study compares whole-genome sequencing data obtained from chemo-naive and chemo-treated samples. The quality of whole-genomic sequencing data is comparable across all samples regardless of chemotherapy status. Inclusion of samples collected post-chemotherapy increased the proportion of late-stage tumors. When comparing matched pre- and post-chemotherapy samples from 10 cases, the mutational signatures, copy number, and SNV mutational profiles reflect the expected heter

SUBMITTER: Noorani A 

PROVIDER: S-EPMC5453324 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature