Transcriptional regulatory dynamics drive coordinated metabolic and neural response to social challenge in mice.

ABSTRACT: Agonistic encounters are powerful effectors of future behavior, and the ability to learn from this type of social challenge is an essential adaptive trait. We recently identified a conserved transcriptional program defining the response to social challenge across animal species, highly enriched in transcription factor (TF), energy metabolism, and developmental signaling genes. To understand the trajectory of this program and to uncover the most important regulatory influences controlling this response, we integrated gene expression data with the chromatin landscape in the hypothalamus, frontal cortex, and amygdala of socially challenged mice over time. The expression data revealed a complex spatiotemporal patterning of events starting with neural signaling molecules in the frontal cortex a

SUBMITTER: Saul MC 

PROVIDER: S-EPMC5453329 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature