The logic of transcriptional regulator recruitment architecture at <i>cis</i>-regulatory modules controlling liver functions.

ABSTRACT: Control of gene transcription relies on concomitant regulation by multiple transcriptional regulators (TRs). However, how recruitment of a myriad of TRs is orchestrated at cis-regulatory modules (CRMs) to account for coregulation of specific biological pathways is only partially understood. Here, we have used mouse liver CRMs involved in regulatory activities of the hepatic TR, NR1H4 (FXR; farnesoid X receptor), as our model system to tackle this question. Using integrative cistromic, epigenomic, transcriptomic, and interactomic analyses, we reveal a logical organization where trans-regulatory modules (TRMs), which consist of subsets of preferentially and coordinately corecruited TRs, assemble into hierarchical combinations at hepatic CRMs. Different combinations of TRMs add

SUBMITTER: Dubois-Chevalier J 

PROVIDER: S-EPMC5453331 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature