Paravascular channels, cisterns, and the subarachnoid space in the rat brain: A single compartment with preferential pathways.

ABSTRACT: Recent evidence suggests an extensive exchange of fluid and solutes between the subarachnoid space and the brain interstitium, involving preferential pathways along blood vessels. We studied the anatomical relations between brain vasculature, cerebrospinal fluid compartments, and paravascular spaces in male Wistar rats. A fluorescent tracer was infused into the cisterna magna, without affecting intracranial pressure. Tracer distribution was analyzed using a 3D imaging cryomicrotome, confocal microscopy, and correlative light and electron microscopy. We found a strong 3D colocalization of tracer with major arteries and veins in the subarachnoid space and large cisterns, attributed to relatively large subarachnoid space volumes around the vessels. Confocal imaging confirmed this colocalizati

SUBMITTER: Bedussi B 

PROVIDER: S-EPMC5453458 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature