VEGF165b Modulates Endothelial VEGFR1-STAT3 Signaling Pathway and Angiogenesis in Human and Experimental Peripheral Arterial Disease.

ABSTRACT:

Rationale

Atherosclerotic-arterial occlusions decrease tissue perfusion causing ischemia to lower limbs in patients with peripheral arterial disease (PAD). Ischemia in muscle induces an angiogenic response, but the magnitude of this response is frequently inadequate to meet tissue perfusion requirements. Alternate splicing in the exon-8 of vascular endothelial growth factor (VEGF)-A results in production of proangiogenic VEGF_xxxa isoforms (VEGF₁₆₅a, 165 for the 165 amino acid product) and antiangiogenic VEGF_xxxb (VEGF₁₆₅b) isoforms.

Objective

The antiangiogenic VEGF_xxxb isoforms are thought to antagonize VEGF_xxxa isoforms and decrease activation of VEGF receptor-2 (VEGFR2), hereunto considered the dominant rec

SUBMITTER: Ganta VC 

PROVIDER: S-EPMC5453503 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature