Measuring changes in transmission of neglected tropical diseases, malaria, and enteric pathogens from quantitative antibody levels.

ABSTRACT:

Background

Serological antibody levels are a sensitive marker of pathogen exposure, and advances in multiplex assays have created enormous potential for large-scale, integrated infectious disease surveillance. Most methods to analyze antibody measurements reduce quantitative antibody levels to seropositive and seronegative groups, but this can be difficult for many pathogens and may provide lower resolution information than quantitative levels. Analysis methods have predominantly maintained a single disease focus, yet integrated surveillance platforms would benefit from methodologies that work across diverse pathogens included in multiplex assays.

Methods/principal findings

We developed an approach to measure changes in transmission from quantitative antibody levels that can

SUBMITTER: Arnold BF 

PROVIDER: S-EPMC5453600 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature