Exploiting a host-commensal interaction to promote intestinal barrier function and enteric pathogen tolerance.

ABSTRACT: Commensal intestinal bacteria can prevent pathogenic infection; however, limited knowledge of the mechanisms by which individual bacterial species contribute to pathogen resistance has restricted their potential for therapeutic application. Here, we examined how colonization of mice with a human commensal Enterococcus faecium protects against enteric infections. We show that E. faecium improves host intestinal epithelial defense programs to limit Salmonella enterica serotype Typhimurium pathogenesis in vivo in multiple models of susceptibility. E. faecium protection is mediated by a unique peptidoglycan hydrolase, SagA, and requires epithelial expression of pattern recognition receptor components and antimicrobial peptides. Ectopic expression of SagA in n

SUBMITTER: Pedicord VA 

PROVIDER: S-EPMC5453653 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature