Regional Gray Matter Volumes as Related to Psychomotor Slowing in Adults with Type 1 Diabetes.

ABSTRACT:

Objective

Psychomotor slowing is a common cognitive complication in type 1 diabetes (T1D), but its neuroanatomical correlates and risk factors are unclear. In nondiabetic adults, smaller gray matter volume (GMV) and presence of white matter hyperintensities are associated with psychomotor slowing. We hypothesize that smaller GMV in prefronto-parietal regions explains T1D-related psychomotor slowing. We also inspect the contribution of microvascular disease and hyperglycemia.

Methods

GMV, white matter hyperintensities (WMH), and glucose levels were measured concurrently with a test of psychomotor speed (Digit Symbol Substitution Test [DSST]) in 95 adults with childhood-onset T1D (mean age/duration = 49/41 years) and 135 similarly aged non-T1D adults. Linear regression models

SUBMITTER: Nunley KA 

PROVIDER: S-EPMC5453835 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature