Neural correlates of RDoC reward constructs in adolescents with diverse psychiatric symptoms: A Reward Flanker Task pilot study.

ABSTRACT:

Background

There has been growing interest under the Research Domain Criteria initiative to investigate behavioral constructs and their underlying neural circuitry. Abnormalities in reward processes are salient across psychiatric conditions and may precede future psychopathology in youth. However, the neural circuitry underlying such deficits has not been well defined. Therefore, in this pilot, we studied youth with diverse psychiatric symptoms and examined the neural underpinnings of reward anticipation, attainment, and positive prediction error (PPE, unexpected reward gain). Clinically, we focused on anhedonia, known to reflect deficits in reward function.

Methods

Twenty-two psychotropic medication-free youth, 16 with psychiatric symptoms, exhibiting a full range of anhedo

SUBMITTER: Bradley KAL 

PROVIDER: S-EPMC5453853 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature