Dataset to delineate changes in association between Akt1 and its interacting partners as a function of active state of Akt1 protein.

ABSTRACT: Akt1 is a multi-functional protein, implicated in multiple human solid tumors. Pertaining to its key role in cell survival, Akt1 is under focus for development of targeted therapies. Functional diversity of Akt1 is a result of its interactions with other proteins; which changes with changing context. This investigation was designed to capture the dynamics of Akt1 Interactome as a function of its active state. Delineating dynamic changes in association of Akt1 with its interactors could help us comprehend how it changes as a function of inhibition of its active form. Similar information on changes in Akt1 interactome as of now is not well explored. Akt1 expressing HEK293 cells were cultured in light and heavy labeled SILAC media. Normal lysine and arginine were incorporated as light labels

SUBMITTER: Gupta N 

PROVIDER: S-EPMC5454128 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature