Alpha2A-adrenergic receptor and eNOS genetic polymorphisms are associated with exercise muscle vasodilatation in apparently healthy individuals.

ABSTRACT:

Purpose

Muscle vasodilatation during exercise has been associated with cardiovascular health and may be influenced by genetic variability. The purpose of this study was to evaluate functional genetic polymorphisms of physiologic pathways related to the regulation of the cardiovascular function (alpha-adrenergic receptors, endothelial nitric oxide synthase and bradykinin B₂ receptor) and exercise muscle vasodilatation in apparently healthy men and women.

Methods

We enrolled 689 individuals without established cardiovascular disease that had attended a check-up program. The vasodilatation was studied with venous occlusion plethysmography and determined by the increase of vascular conductance during handgrip exercise. Genotypes for ADRA1A Arg347Cys (rs1048101), ADRA2

SUBMITTER: Amorim Belo Nunes R 

PROVIDER: S-EPMC5454168 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature