Gradual loading ameliorates maladaptation in computational simulations of vein graft growth and remodelling.

ABSTRACT: Vein graft failure is a prevalent problem in vascular surgeries, including bypass grafting and arteriovenous fistula procedures in which veins are subjected to severe changes in pressure and flow. Animal and clinical studies provide significant insight, but understanding the complex underlying coupled mechanisms can be advanced using computational models. Towards this end, we propose a new model of venous growth and remodelling (G&R) based on a constrained mixture theory. First, we identify constitutive relations and parameters that enable venous adaptations to moderate perturbations in haemodynamics. We then fix these relations and parameters, and subject the vein to a range of combined loads (pressure and flow), from moderate to severe, and identify plausible mechanisms of adaptation ver

SUBMITTER: Ramachandra AB 

PROVIDER: S-EPMC5454282 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature