Comparison of 10 murine models reveals a distinct biomechanical phenotype in thoracic aortic aneurysms.

ABSTRACT: Thoracic aortic aneurysms are life-threatening lesions that afflict young and old individuals alike. They frequently associate with genetic mutations and are characterized by reduced elastic fibre integrity, dysfunctional smooth muscle cells, improperly remodelled collagen and pooled mucoid material. There is a pressing need to understand better the compromised structural integrity of the aorta that results from these genetic mutations and renders the wall vulnerable to dilatation, dissection or rupture. In this paper, we compare the biaxial mechanical properties of the ascending aorta from 10 murine models: wild-type controls, acute elastase-treated, and eight models with genetic mutations affecting extracellular matrix proteins, transmembrane receptors, cytoskeletal proteins, or intracel

SUBMITTER: Bellini C 

PROVIDER: S-EPMC5454287 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature