Inferring single-cell behaviour from large-scale epithelial sheet migration patterns.

ABSTRACT: Cell migration plays an important role in a wide variety of biological processes and can incorporate both individual cell motion and collective behaviour. The emergent properties of collective migration are receiving increasing attention as collective motion's role in diseases such as metastatic cancer becomes clear. Yet, how individual cell behaviour influences large-scale, multi-cell collective motion remains unclear. In this study, we provide insight into the mechanisms behind collective migration by studying cell migration in a spreading monolayer of epithelial MCF10A cells. We quantify migration using particle image velocimetry and find that cell groups have features of motion that span multiple length scales. Comparing our experimental results to a model of collective cell migration,

SUBMITTER: Lee RM 

PROVIDER: S-EPMC5454303 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature