Mechanotransmission in endothelial cells subjected to oscillatory and multi-directional shear flow.

ABSTRACT: Local haemodynamics are linked to the non-uniform distribution of atherosclerosic lesions in arteries. Low and oscillatory (reversing in the axial flow direction) wall shear stress (WSS) induce inflammatory responses in endothelial cells (ECs) mediating disease localization. The objective of this study is to investigate computationally how the flow direction (reflected in WSS variation on the EC surface over time) influences the forces experienced by structural components of ECs that are believed to play important roles in mechanotransduction. A three-dimensional, multi-scale, multi-component, viscoelastic model of focally adhered ECs is developed, in which oscillatory WSS (reversing or non-reversing) parallel to the principal flow direction, or multi-directional oscillatory WSS with rever

SUBMITTER: Dabagh M 

PROVIDER: S-EPMC5454307 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature