Development of a micro-array to detect human and mouse microRNAs and characterization of expression in human organs.

ABSTRACT: MicroRNAs (miRNAs) are believed to play important roles in developmental and other cellular processes by hybridizing to complementary target mRNA transcripts. This results in either cleavage of the hybridized transcript or negative regulation of translation. Little is known about the regulation or pattern of miRNA expression. The predicted presence of numerous miRNA sequences in higher eukaryotes makes it highly likely that the expression levels of individual miRNA molecules themselves should play an important role in regulating multiple cellular processes. Therefore, determining the pattern of global miRNA expression levels in mammals and other higher eukaryotes is essential to help understand both the mechanism of miRNA transcriptional regulation as well as to help identify miRNA regulat

SUBMITTER: Sun Y 

PROVIDER: S-EPMC545483 | biostudies-literature | 2004 Dec

REPOSITORIES: biostudies-literature