Neurotrauma: The Crosstalk between Neurotrophins and Inflammation in the Acutely Injured Brain.

ABSTRACT: Traumatic brain injury (TBI) is a major cause of morbidity and mortality among young individuals worldwide. Understanding the pathophysiology of neurotrauma is crucial for the development of more effective therapeutic strategies. After the trauma occurs, immediate neurologic damage is produced by the traumatic forces; this primary injury triggers a secondary wave of biochemical cascades together with metabolic and cellular changes, called secondary neural injury. In the scenario of the acutely injured brain, the ongoing secondary injury results in ischemia and edema culminating in an uncontrollable increase in intracranial pressure. These areas of secondary injury progression, or areas of "traumatic penumbra", represent crucial targets for therapeutic interventions. Neurotrophins are a cla

SUBMITTER: da Silva Meirelles L 

PROVIDER: S-EPMC5454991 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature