The genome of the heartwater agent Ehrlichia ruminantium contains multiple tandem repeats of actively variable copy number.

ABSTRACT: Heartwater, a tick-borne disease of domestic and wild ruminants, is caused by the intracellular rickettsia Ehrlichia ruminantium (previously known as Cowdria ruminantium). It is a major constraint to livestock production throughout subSaharan Africa, and it threatens to invade the Americas, yet there is no immediate prospect of an effective vaccine. A shotgun genome sequencing project was undertaken in the expectation that access to the complete protein coding repertoire of the organism will facilitate the search for vaccine candidate genes. We report here the complete 1,516,355-bp sequence of the type strain, the stock derived from the South African Welgevonden isolate. Only 62% of the genome is predicted to be coding sequence, encoding 888 proteins and 41 stable RNA species. The most str

SUBMITTER: Collins NE 

PROVIDER: S-EPMC545511 | biostudies-literature | 2005 Jan

REPOSITORIES: biostudies-literature