SIRT1 ameliorates oxidative stress induced neural cell death and is down-regulated in Parkinson's disease.

ABSTRACT:

Background

Sirtuins (SIRTs) are NAD⁺ dependent lysine deacetylases which are conserved from bacteria to humans and have been associated with longevity and lifespan extension. SIRT1, the best studied mammalian SIRT is involved in many physiological and pathological processes and changes in SIRT1 have been implicated in neurodegenerative disorders, with SIRT1 having a suggested protective role in Parkinson's disease. In this study, we determined the effect of SIRT1 on cell survival and α-synuclein aggregate formation in SH-SY5Y cells following oxidative stress.

Results

Over-expression of SIRT1 protected SH-SY5Y cells from toxin induced cell death and the protection conferred by SIRT1 was partially independent of its deacetylase activity, which was associated with th

SUBMITTER: Singh P 

PROVIDER: S-EPMC5455114 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature