Review of studies on the fat mass and obesity-associated (FTO) gene interactions with environmental factors affecting on obesity and its impact on lifestyle interventions.

ABSTRACT:

Background

The prevalence of obesity is influenced by environmental and genetic factors. Recently, it has been reported that an interaction between genotype and environmental factors can affect each other's effects on the phenotype. The purpose of this study is to evaluate the recent studies on the fat mass and obesity-associated (FTO) gene interactions with environmental factors affecting on obesity and the impact of these interactions on the success level of the lifestyle intervention.

Methods

All articles published in English from June 1990 to June 2015 were studied.

Results

In most studies, the role of the FTO risk alleles for obesity is significantly intensified through reduced physical activity and high calorie diet. Furthermore, the results of studies about the

SUBMITTER: Kalantari N 

PROVIDER: S-EPMC5455327 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature