Bacterial components are the major contributors to the macrophage stimulating activity exhibited by extracts of common edible mushrooms.

ABSTRACT: Recent studies have indicated that a major contributor to the innate immune enhancing properties of some medicinal plants is derived from the cell wall components of bacteria colonizing these plants. The purpose of the current study was to assess if the bacteria present within edible and medicinal mushrooms substantially contribute to the innate immune stimulating potential of these mushrooms. Whole mushrooms from thirteen types of edible fungi and individual parts from Agaricus bisporus were analyzed for in vitro macrophage activation as well as bacterial lipopolysaccharides (LPS) content, cell load, and community composition. Substantial variation between samples was observed in macrophage activation (over 500-fold), total bacterial load (over 200-fold), and LPS content (over 10 million-

SUBMITTER: Tyler HL 

PROVIDER: S-EPMC5455775 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature