A scale of functional divergence for yeast duplicated genes revealed from analysis of the protein-protein interaction network.

ABSTRACT:

Background

Studying the evolution of the function of duplicated genes usually implies an estimation of the extent of functional conservation/divergence between duplicates from comparison of actual sequences. This only reveals the possible molecular function of genes without taking into account their cellular function(s). We took into consideration this latter dimension of gene function to approach the functional evolution of duplicated genes by analyzing the protein-protein interaction network in which their products are involved. For this, we derived a functional classification of the proteins using PRODISTIN, a bioinformatics method allowing comparison of protein function. Our work focused on the duplicated yeast genes, remnants of an ancient whole-genome duplication.

Results<

SUBMITTER: Baudot A 

PROVIDER: S-EPMC545596 | biostudies-literature | 2004

REPOSITORIES: biostudies-literature