Loss of Heterozygosity Drives Adaptation in Hybrid Yeast.

ABSTRACT: Hybridization is often considered maladaptive, but sometimes hybrids can invade new ecological niches and adapt to novel or stressful environments better than their parents. The genomic changes that occur following hybridization that facilitate genome resolution and/or adaptation are not well understood. Here, we examine hybrid genome evolution using experimental evolution of de novo interspecific hybrid yeast Saccharomyces cerevisiae × Saccharomyces uvarum and their parentals. We evolved these strains in nutrient-limited conditions for hundreds of generations and sequenced the resulting cultures identifying numerous point mutations, copy number changes, and loss of heterozygosity (LOH) events, including species-biased amplification of nutrient transporters. We focused on a particularly in

SUBMITTER: Smukowski Heil CS 

PROVIDER: S-EPMC5455960 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature