Origin and Evolutionary Alteration of the Mitochondrial Import System in Eukaryotic Lineages.

ABSTRACT: Protein transport systems are fundamentally important for maintaining mitochondrial function. Nevertheless, mitochondrial protein translocases such as the kinetoplastid ATOM complex have recently been shown to vary in eukaryotic lineages. Various evolutionary hypotheses have been formulated to explain this diversity. To resolve any contradiction, estimating the primitive state and clarifying changes from that state are necessary. Here, we present more likely primitive models of mitochondrial translocases, specifically the translocase of the outer membrane (TOM) and translocase of the inner membrane (TIM) complexes, using scrutinized phylogenetic profiles. We then analyzed the translocases' evolution in eukaryotic lineages. Based on those results, we propose a novel evolutionary scenario fo

SUBMITTER: Fukasawa Y 

PROVIDER: S-EPMC5455965 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature