Influence of the definition of "metabolically healthy obesity" on the progression of coronary artery calcification.

ABSTRACT:

Objectives

Debates whether metabolically healthy obesity (MHO) increases the cardiovascular risk might be due to the metabolic instability of MHO or the absence of a perfect definition of MHO. Therefore, we aimed to investigate the influence of the MHO phenotype on the coronary artery calcium score (CACS) progression according to definition of MHO.

Methods

We analyzed a retrospective cohort with a CACS of 0 at baseline and available serial CACS measurements taken ≥ 12 months apart (n = 1,218). Obesity was defined as BMI ≥ 25 kg/m2, and MHO was defined as obesity accompanied by ≤ 1 (MHO class I) or 0 (MHO class II) components of metabolic syndrome (MetS).

Results

During a median follow-up of 45 months, 32.2% of MHO class I and 10.2% of MHO class II subjects developed M

SUBMITTER: Yoon JW 

PROVIDER: S-EPMC5456095 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature