Is the efficacy of antidepressants in panic disorder mediated by adverse events? A mediational analysis.

ABSTRACT: It has been hypothesised that the perception of adverse events in placebo-controlled antidepressant clinical trials may induce patients to conclude that they have been randomized to the active arm of the trial, leading to the breaking of blind. This may enhance the expectancies for improvement and the therapeutic response. The main objective of this study is to test the hypothesis that the efficacy of antidepressants in panic disorder is mediated by the perception of adverse events. The present analysis is based on a systematic review of published and unpublished randomised trials comparing antidepressants with placebo for panic disorder. The Baron and Kenny approach was applied to investigate the mediational role of adverse events in the relationship between antidepressants treatment and

SUBMITTER: Bighelli I 

PROVIDER: S-EPMC5456299 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature