Thyroid peroxidase (TPO) expressed in thyroid and breast tissues shows similar antigenic properties.

ABSTRACT:

Background

Thyroid peroxidase (TPO) is essential for physiological function of the thyroid gland. The high prevalence of thyroid peroxidase antibodies (TPOAbs) in patients with breast cancer and their protective role had previously been demonstrated, indicating a link between breast cancer and thyroid autoimmunity. Recently, TPO was shown to be present in breast cancer tissue samples but its antigenicity has not been analyzed.

Methods

In this study, we investigated TPO expression levels in a series of fifty-six breast cancer samples paired with normal (peri-tumoral) tissue and its antigenic activity using a panel of well-characterized murine anti-human TPOAbs.

Results

We have shown that TPO transcripts were present in both normal and cancer tissue samples, although th

SUBMITTER: Godlewska M 

PROVIDER: S-EPMC5456382 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature