Pheromone-sensing neurons regulate peripheral lipid metabolism in Caenorhabditis elegans.

ABSTRACT: It is now established that the central nervous system plays an important role in regulating whole body metabolism and energy balance. However, the extent to which sensory systems relay environmental information to modulate metabolic events in peripheral tissues has remained poorly understood. In addition, it has been challenging to map the molecular mechanisms underlying discrete sensory modalities with respect to their role in lipid metabolism. In previous work our lab has identified instructive roles for serotonin signaling as a surrogate for food availability, as well as oxygen sensing, in the control of whole body metabolism. In this study, we now identify a role for a pair of pheromone-sensing neurons in regulating fat metabolism in C. elegans, which has emerged as a tractable and hig

SUBMITTER: Hussey R 

PROVIDER: S-EPMC5456406 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature