Cortical-amygdala volumetric ratios predict onset of symptoms of psychosis in 22q11.2 deletion syndrome.

ABSTRACT: Dysfunction of cortical circuitry involving prefrontal cortex, cingulate gyrus and mesial temporal lobe has been implicated in the pathophysiology of psychotic symptoms. 22q11.2 deletion syndrome (22q11DS) is a neurogenetic disorder that comports a 25-fold increased risk of developing psychosis. Morphological changes in the neuroanatomy of this syndrome may represent a biological risk factor for the development of psychosis. The present study explored ratios between cortical volumes and the amygdala. We also explored relationships between these ratios and the eventual development of psychosis in youth with 22q11DS. A group of 73 individuals with 22q11DS, 32 community controls, and 27 unaffected siblings were followed every three years, at four timepoints. We analyzed baseline ratios betwee

SUBMITTER: Berhanu D 

PROVIDER: S-EPMC5456453 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature