The role of microRNA-155/liver X receptor pathway in experimental and idiopathic pulmonary fibrosis.

ABSTRACT:

Background

Idiopathic pulmonary fibrosis (IPF) is progressive and rapidly fatal. Improved understanding of pathogenesis is required to prosper novel therapeutics. Epigenetic changes contribute to IPF; therefore, microRNAs may reveal novel pathogenic pathways.

Objectives

We sought to determine the regulatory role of microRNA (miR)-155 in the profibrotic function of murine lung macrophages and fibroblasts, IPF lung fibroblasts, and its contribution to experimental pulmonary fibrosis.

Methods

Bleomycin-induced lung fibrosis in wild-type and miR-155^-/- mice was analyzed by histology, collagen, and profibrotic gene expression. Mechanisms were identified by in silico and molecular approaches and validated in mouse lung fibroblasts and macrophages, and in IPF lung

SUBMITTER: Kurowska-Stolarska M 

PROVIDER: S-EPMC5457127 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature